Alternative Polyadenylation of Mammalian Transcripts Is Generally Deleterious, Not Adaptive
نویسندگان
چکیده
منابع مشابه
Dysfunctional transcripts are formed by alternative polyadenylation in OPMD
Post-transcription mRNA processing in the 3'-untranslated region (UTR) of transcripts alters mRNA landscape. Alternative polyadenylation (APA) utilization in the 3'-UTR often leads to shorter 3'-UTR affecting mRNA stability, a process that is regulated by PABPN1. In skeletal muscles PABPN1 levels reduce with age and a greater decrease in found in Oculopharyngeal muscular dystrophy (OPMD). OPMD ...
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ژورنال
عنوان ژورنال: Cell Systems
سال: 2018
ISSN: 2405-4712
DOI: 10.1016/j.cels.2018.05.007